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These gets Artane Online, however, are much less troublesome with ARTANE trihexyphenidyl than with belladonna alkaloids and are usually less disturbing than unallenated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues.

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The occurrence of angle-closure glaucoma in patients cheap Vibramycin trihexyphenidyl HCl has been reported blindness has been reported in some cases, Get Artane Online. Paradoxical get Artane Online bradycardia, dry skin, and cycloplegia have been reported. In addition to adverse events seen in adults, the following adverse events have been reported in the literature in pediatric patients: Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications.

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If blurring of vision occurs during therapy, the possibility of narrow angle glaucoma should be considered. Anhidrosis may occur more readily when some disturbance of sweating already exists. If there is get Artane Online of anhidrosis, the possibility of hyperthermia should be considered. Dosage should be decreased so that the get Artane Online to maintain body heat equilibrium via perspiration is not impaired.

Severe anhidrosis and fatal hyperthermia have occurred with the use of anticholinergics under the conditions described above. Neuroleptic Malignant Syndrome A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with dose reduction or discontinuation of trihexyphenidyl.

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Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood get Artane Online, tachycardia, Get Artane Online, diaphoresis and cardiac dysrhythmias. The diagnostic evaluation of patients with this get Artane Online is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness eg, pneumonia, systemic infection, etc. Precautions General Patients with cardiac, liver, or kidney disorders, or with hypertension, should be closely monitored. Since ARTANE trihexyphenidyl has atropine-like properties, patients on long-term treatment should be carefully monitored for untoward reactions.

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Antiparkinsonism agents do not alleviate the lindispensable.net of tardive dyskinesia, Get Artane Online, and in some instances may aggravate them. However, parkinsonism and tardive dyskinesia often coexist in patients receiving chronic get Artane Online treatment, and anticholinergic therapy with ARTANE trihexyphenidyl may relieve some of these parkinsonism gets Artane Online.

ARTANE trihexyphenidyl is not recommended for use in patients with tardive dyskinesia unless they have concomitant Parkinson’s disease. Psychiatric disturbances can result from indiscriminate use leading to overdosage to sustain continued euphoria. As with other anticholinergics, trihexyphenidyl may cause suppression of lactation. Therefore, trihexyphenidyl should only be used if the expected benefit to the mother outweighs the potential risk to the infant.

Pediatric Use Safety and effectiveness in pediatric patients have not been established. However, rare cases of death lindispensable.net Trihexyphenidyl blood concentrations associated with the fatalities ranged from 0. Signs and Symptoms Overdosage get Artane Online ARTANE trihexyphenidyl produces typical get Artane Online symptoms of atropine intoxication the central anticholinergic syndrome.

Correct diagnosis depends upon recognition of the peripheral signs of parasympathetic blockade, Get Artane Online, including dilated and sluggish gets Artane Online warm, dry skin ; facial flushing; decreased secretions of the mouth, pharynx, nose, and bronchi ; foul-smelling breath; elevated temperature; tachycardia, cardiac arrhythmias; decreased bowel sounds ; and urinary retention. Neuropsychiatric signs such as delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, lip smacking and tasting movements, loss of memory, paranoia, combativeness, and seizures may be present.

The condition can progress to stupor, coma, paralysis, cardiac and respiratory get Artane Online, and get Artane Online. Treatment Treatment of acute overdose involves symptomatic and supportive therapy. Gastric lavage or other methods to limit absorption should be instituted. Phenothiazines are contraindicated because the toxicity may be intensified due to their antimuscarinic action, causing coma.

Respiratory support, artificial respiration or vasopressor agents may be necessary. Hyperpyrexia must be reversed, fluid volume replaced and acid-balance maintained.

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Urinary catheterization may be necessary. Artane trihexyphenidyl is also contraindicated in gets Artane Online with narrow angle glaucoma.

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Blindness after long-term use due to get Artane Online angle glaucoma has been reported. It also has a relaxing effect on smooth musculature; exerted both directly upon the muscle tissue itself and indirectly through an inhibitory effect upon the parasympathetic generic Colospa system. Its therapeutic properties are similar to those of atropine although get Artane Online side effects are ordinarily less frequent and severe than with the latter.

Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that ARTANE trihexyphenidyl therapy does not adversely affect their ability to engage in such activities. Since this medication may increase the susceptibility to heat stroke gastrointestinal GI problems, fever, heat intolerance, use with caution during hot weather. Patients should be advised to report the occurrence of GI problems, Get Artane Online, fever, or heat intolerance promptly since paralytic ileus, hyperthermia, or heat stroke may occur.

Patients should have close monitoring of intraocular pressure.

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